1569309-92-7

1569309-92-7 structure

Name: DBIBB
Chemical Name: 2-{[4-(1,3-Dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)butyl]sulfamoyl}benzoic acid
CAS Number: 1569309-92-7
Molecular Formula: C₂₃H₂₀N₂O₆S
Molecular Weight: 452.480
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2020-01-12 21:00:15
Modify Date: 2024-01-10 18:08:47
A potent and specific, nonlipid agonist of LPA2 receptor with EC50 of 100 nM, without activating or inhibiting LPA1/3/4/5 receptors; displays 33-fold increased potency over GRI977143; mitigates the gastrointestinal radiation syndrome, increases intestinal crypt survival and enterocyte proliferation and reduces apoptosis; enhances DNA repair by augmenting the resolution of γ-H2AX foci, increases clonogenic survival of irradiated IEC-6 cells, attenuates the radiation-induced death of human CD34(+) hematopoietic progenitors and enhances the survival of the granulocyte/macrophage lineage in mice.

Name	2-{[4-(1,3-Dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)butyl]sulfamoyl}benzoic acid
Synonyms	2-{[4-(1,3-Dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)butyl]sulfamoyl}benzoic acid Benzoic acid, 2-[[[4-(1,3-dioxo-1H-benz[de]isoquinolin-2(3H)-yl)butyl]amino]sulfonyl]-

Description	A potent and specific, nonlipid agonist of LPA2 receptor with EC50 of 100 nM, without activating or inhibiting LPA1/3/4/5 receptors; displays 33-fold increased potency over GRI977143; mitigates the gastrointestinal radiation syndrome, increases intestinal crypt survival and enterocyte proliferation and reduces apoptosis; enhances DNA repair by augmenting the resolution of γ-H2AX foci, increases clonogenic survival of irradiated IEC-6 cells, attenuates the radiation-induced death of human CD34(+) hematopoietic progenitors and enhances the survival of the granulocyte/macrophage lineage in mice.
References	References 1. Patil R, et al. Chem Biol. 2015 Feb 19;22(2):206-16. 2. Knowlden SA, et al. Am J Respir Cell Mol Biol. 2016 Mar;54(3):402-9. View Related Products by Target Lysophospholipid Receptor