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Hosenkoside A

Names

[ CAS No. ]:
156791-82-1

[ Name ]:
Hosenkoside A

[Synonym ]:
β-D-Glucopyranoside, (1R,2S,4aR,4bR,6'S,6aR,7R,8S,10aR,10bR,12aS)-7-[(β-D-glucopyranosyloxy)methyl]octadecahydro-1-hydroxy-6'-[(1S)-2-hydroxy-1-methylethyl]-4a,4b,7,10a-tetramethylspiro[chrysene -2(1H),3'(4'H)-[2H]pyran]-8-yl 2-O-β-D-glucopyranosyl-
(1R,2S,4aR,4bR,6'S,6aR,7R,8S,10aR,10bR,12aS)-7-[(β-D-Glucopyranosyloxy)methyl]-1-hydroxy-6'-[(2S)-1-hydroxy-2-propanyl]-4a,4b,7,10a-tetramethyloctadecahydro-1H,4'H-spiro[chrysene-2,3'-pyran]-8-yl 2 -O-β-D-glucopyranosyl-β-D-glucopyranoside
Hosenkoside A

Biological Activity

[Description]:

Hosenkoside A is a baccharane glycoside isolated from the seeds of impatiens balsamina.

[Related Catalog]:

Signaling Pathways >> Others >> Others
Natural Products >> Saccharides and Glycosides
Research Areas >> Inflammation/Immunology

[In Vivo]

The mean peak concentrations of hosenkoside A in rats after oral administration of total saponins of Semen Impatientis is 162.08±139.87 ng/mL, occurring at times of 0.67 h. The terminal half-lives of hosenkoside A is 5.39±2.06h[1].

[Animal admin]

Male Wistar rats (7 weeks old, 220±20 g, n=6) are fasted for 12 h. Total saponins of Semen Impatientis at a dose of 300 mg (in 10 mL)/kg are orally administered to rats using a gastric gavage tube. The doses of hosenkoside A is12.4 mg/kg for an oral dose of 300 mg/kg total saponins. Blood samples (0.20 mL) are collected from suborbital vein into heparinized tubes before administration (0 min), and 0.08, 0.25, 0.5, 0.75, 1, 1.5, 2, 4, 6, 8, 12 and 24 h after dosing.

[References]

[1]. Yu X, et al. An LC-MS/MS method for simultaneous determination of hosenkoside A and hosenkoside K from Semen Impatientis in rat plasma and its application to a pharmacokinetic study. Biomed Chromatogr. 2017 Mar;31(3).


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Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
1075.9±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C48H82O20

[ Molecular Weight ]:
979.153

[ Flash Point ]:
604.5±34.3 °C

[ Exact Mass ]:
978.539917

[ PSA ]:
327.60000

[ LogP ]:
0.07

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.626

[ Storage condition ]:
2-8℃

Related Compounds