MART-1 (26-35) (human) trifluoroacetate salt

Names

[ Name ]:
MART-1 (26-35) (human) trifluoroacetate salt

[Synonym ]:
Melan-A,MART 1 (26-35)
ANTIGEN SK29-AA (26-35) (HUMAN)
L-α-Glutamyl-L-alanyl-L-alanylglycyl-L-isoleucylglycyl-L-isoleucyl-L-leucyl-L-threonyl-L-valine
MART-1 (26-35) (HUMAN)
GLU-ALA-ALA-GLY-ILE-GLY-ILE-LEU-THR-VAL
ANTIGEN LB39-AA (26-35) (HUMAN)
MELAN-A PROTEIN (26-35) (HUMAN)
EAAGIGILTV
L-Valine, L-α-glutamyl-L-alanyl-L-alanylglycyl-L-isoleucylglycyl-L-isoleucyl-L-leucyl-L-threonyl-
MART-1 (26-35),human (3)
MELAN-A
MART 1 (26-35)

Biological Activity

[Description]:

MART-1 (26-35) is amino acid residue 26 to 35 of MART-1 protein.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Peptides

Research Areas >> Inflammation/Immunology

[In Vitro]

MART-1 (Melan-A) gene is 18 kb long and comprises five exons. It is expressed in most melanoma tumor samples, and among normal cells, only in melanocytes[1]. In cancer immunotherapy, epitopes and variants derived from the MART-1/Melan-A protein are widely used as clinical vaccines. The epitopes spanning amino acid residues 26–35 and 27–35 from the MART-1/Melan-A protein, highly expressed in melanoma cells, provide a prime example of T cell recognition of multiple peptides and the use of peptide variants designed to elicit altered immunological responses[2].

[References]

[1]. Coulie PG, et al. A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas. J Exp Med. 1994 Jul 1;180(1):35-42.

[2]. Borbulevych OY, et al. Structures of MART-126/27-35 Peptide/HLA-A2 complexes reveal a remarkable disconnect between antigen structural homology and T cell recognition. J Mol Biol. 2007 Oct 5;372(5):1123-36.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
1358.4±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₄₂H₇₄N₁₀O₁₄

[ Molecular Weight ]:
943.096

[ Flash Point ]:
775.3±34.3 °C

[ Exact Mass ]:
942.538574

[ PSA ]:
382.75000

[ LogP ]:
1.19

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.527

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.