moiramide B

Names

[ Name ]:
moiramide B

[Synonym ]:
Benzenepropanamide, N-[(1S)-2-methyl-1-[[(3R,4S)-4-methyl-2,5-dioxo-3-pyrrolidinyl]carbonyl]propyl]-β-[[(2E,4E)-1-oxo-2,4-hexadien-1-yl]amino]-, (βS)-
(2E,4E)-N-[(1S)-3-({(2S)-3-Methyl-1-[(3R,4S)-4-methyl-2,5-dioxo-3-pyrrolidinyl]-1-oxo-2-butanyl}amino)-3-oxo-1-phenylpropyl]-2,4-hexadienamide
moiramide B
(2E,4E)-N-[(1S)-3-({(2S)-3-methyl-1-[(3R,4S)-4-methyl-2,5-dioxopyrrolidin-3-yl]-1-oxobutan-2-yl}amino)-3-oxo-1-phenylpropyl]hexa-2,4-dienamide

Biological Activity

[Description]:

Moiramide B is a potent acetyl-CoA carboxylase (ACC) inhibitor with an IC50 value of 6 nM. Moiramide B has antibacterial activity[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

Moiramide B (compound 3; 0.012-25 μM; 大肠杆菌）具有抗菌活性，对于 WT、WT+ PMBN、ΔacrAB、ΔacrAB+PMBN、ΔtolC 和 ΔtolC+ PMBN 的 MIC 值分别为 >25、3.13、25、0.39、1.56、和 0.1 μM[1]。

[References]

[1]. Cifone MT, et, al. Heterobivalent Inhibitors of Acetyl-CoA Carboxylase: Drug Target Residence Time and Time-Dependent Antibacterial Activity. J Med Chem. 2022 Dec 22;65(24):16510-16525.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
772.9±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₅H₃₁N₃O₅

[ Molecular Weight ]:
453.531

[ Flash Point ]:
238.5±33.0 °C

[ Exact Mass ]:
453.226379

[ LogP ]:
2.25

[ Vapour Pressure ]:
0.0±2.6 mmHg at 25°C

[ Index of Refraction ]:
1.548

Related Compounds

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