(Rac)-RK-682

Names

[ Name ]:
(Rac)-RK-682

[Synonym ]:
ANTIBIOTIC RK-682
3-hexadecanoyl-5-hydroxymethyl-tetronic acid
ANTIBIOTIC TAN 1364B

Biological Activity

[Description]:

(Rac)-RK-682, a racemate of RK-682, is a protein tyrosine phosphatases (PTPases) inhibitor. (Rac)-RK-682 inhibits protein tyrosine phosphatase 1B (PTP-1B), low molecular weight protein tyrosine phosphatases (LMW-PTP), and cell division cycle 25B (CDC-25B) with IC50s of 8.6 μM, 12.4 μM, and 0.7 μM, respectively[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase

[Target]

IC50: 8.6 μM (PTP-1B), 12.4 μM (LMW-PTP), and 0.7 μM (CDC-25B) [1]

[References]

[1]. Vânia M T Carneiro, et al. Is RK-682 a promiscuous enzyme inhibitor? Synthesis and in vitro evaluation of protein tyrosine phosphatase inhibition of racemic RK-682 and analogues. Eur J Med Chem. 2015 Jun 5;97:42-54.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₃₆O₅

[ Molecular Weight ]:
368.51

[ Exact Mass ]:
368.25600

[ PSA ]:
83.83000

[ LogP ]:
4.76660

Related Compounds

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