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6-(trifluoromethyl)pyrimidin-4-ol

Names

[ CAS No. ]:
1546-78-7

[ Name ]:
6-(trifluoromethyl)pyrimidin-4-ol

[Synonym ]:
6-(Trifluoromethyl)-4(1H)-pyrimidinone
4-Hydroxy-6-(trifluoromethyl)pyrimidine
4-Pyrimidinol, 6-(trifluoromethyl)-
4-​Hydroxy-​6-​(trifluoromethyl)​pyrimidine
6-TrifluoroMethyl-4-pyriMidinol
6-(trifluoromethyl)-1H-pyrimidin-4-one
6-(trifluoromethyl)pyrimidin-4-ol
MFCD00192530
4-Hydroxy-6-trifluoromethylpyrimidine

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
229.0±35.0 °C at 760 mmHg

[ Melting Point ]:
169-171 °C(lit.)

[ Molecular Formula ]:
C5H3F3N2O

[ Molecular Weight ]:
164.085

[ Flash Point ]:
92.3±25.9 °C

[ Exact Mass ]:
164.019745

[ PSA ]:
46.01000

[ LogP ]:
0.74

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.456

[ Storage condition ]:
2-8°C

MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933599090

Synthetic Route

Precursor & DownStream

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Synthesis and antitumor activity of novel 10-substituted camptothecin analogues.

Bioorg. Med. Chem. 14(21) , 7175-82, (2006)

In an attempt to improve the antitumor activity and decrease the cytotoxicity of camptothecin, 18 new 10-substituted camptothecin derivatives were prepared. The cytotoxicity in vitro on cancer cell li...


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