SB 204990
Names
[ CAS No. ]:
154566-12-8
[ Name ]:
SB 204990
Biological Activity
[Description]:
SB 204990 is a potent and specific inhibitor of ATP citrate lyase (ACLY) enzyme.
[Related Catalog]:
[Target]
ACLY[1].
[In Vitro]
SB204990 (SB) is a specific inhibitor of ACLY enzyme. SB204990 treatment leads to a decrease in cytosolic Ac-CoA level and is thus expected to decrease acetylated and active β-catenin levels[1].
[In Vivo]
SB 204990, when administered orally to rats, is absorbed into the systemic circulation. When administered in the diet (0.05-0.25%, w/w) for 1 week, SB 204990 causes a dose-related decrease in plasma cholesterol (by up to 46%) and triglyceride levels (by up to 80%) in rats. SB 204990 (25 mg/kg per day) also decreases plasma cholesterol levels (by up to 23%) and triglyceride levels (by up to 38%) in the dog, preferentially decreasing low-density lipoprotein compared with high-density lipoprotein cholesterol levels[2].
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Molecular Formula ]:
C18H22Cl2O5
[ Molecular Weight ]:
389.27000
[ Exact Mass ]:
388.08400
[ PSA ]:
83.83000
[ LogP ]:
4.00770
[ Storage condition ]:
2-8℃