154566-12-8

154566-12-8 structure

Name: SB 204990
Chemical Name: 2-((3R,5S)-5-(6-(2,4-dichlorophenyl)hexyl)-3-hydroxy-2-oxotetrahydrofuran-3-yl)acetic acid
CAS Number: 154566-12-8
Molecular Formula: C₁₈H₂₂Cl₂O₅
Molecular Weight: 389.27000
Catalog: Signaling Pathways Metabolic Enzyme/Protease ATP Citrate Lyase
Create Date: 2018-06-08 19:30:10
Modify Date: 2024-01-02 20:34:19
SB 204990 is a potent and specific inhibitor of ATP citrate lyase (ACLY) enzyme.

Name	2-((3R,5S)-5-(6-(2,4-dichlorophenyl)hexyl)-3-hydroxy-2-oxotetrahydrofuran-3-yl)acetic acid

Description	SB 204990 is a potent and specific inhibitor of ATP citrate lyase (ACLY) enzyme.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> ATP Citrate Lyase Research Areas >> Metabolic Disease
Target	ACLY[1].
In Vitro	SB204990 (SB) is a specific inhibitor of ACLY enzyme. SB204990 treatment leads to a decrease in cytosolic Ac-CoA level and is thus expected to decrease acetylated and active β-catenin levels[1].
In Vivo	SB 204990, when administered orally to rats, is absorbed into the systemic circulation. When administered in the diet (0.05-0.25%, w/w) for 1 week, SB 204990 causes a dose-related decrease in plasma cholesterol (by up to 46%) and triglyceride levels (by up to 80%) in rats. SB 204990 (25 mg/kg per day) also decreases plasma cholesterol levels (by up to 23%) and triglyceride levels (by up to 38%) in the dog, preferentially decreasing low-density lipoprotein compared with high-density lipoprotein cholesterol levels[2].
References	[1]. Shares BH, et al. Active mitochondria support osteogenic differentiation by stimulating β-catenin acetylation. J Biol Chem. 2018 Oct 12;293(41):16019-16027. [2]. Pearce NJ, et al. The role of ATP citrate-lyase in the metabolic regulation of plasma lipids. Hypolipidaemic effects of SB-204990, a lactone prodrug of the potent ATP citrate-lyase inhibitor SB-201076. Biochem J. 1998 Aug 15;334 ( Pt 1):113-9.