Cadrofloxacin

Names

[ Name ]:
Cadrofloxacin

[Synonym ]:
3-Quinolinecarboxylic acid,1-cyclopropyl-8-(difluoroMethoxy)-6-fluoro-1,4-dihydro-7-[(3S)-3-Methyl-1-piperazinyl]-4-oxo
1-cyclopropyl-8-(difluoromethoxy)-6-fluoro-7-[(3S)-3-methylpiperazin-1-yl]-4-oxo-quinoline-3-carboxylic acid
Caderofloxacin

Biological Activity

[Description]:

Cadrofloxacin (Caderofloxacin; CS-940), a orally active fluoroquinolone, is effective against aerobic/anaerobic Gram-positive and Gram-negative bacteria. Cadrofloxacin can be used for the research of infectious diseases[1][2][3].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

Cadrofloxacin against M.tuberculosis with a MIC50 of 0.25 μg/mL[1]. Cadrofloxacin against Acinetobacter spp. and Stenotrophomonas (Xanthomonas) maltophilia with MIC90s of 0.03 and 2 μg/ml, respectively[2]. Cadrofloxacin against Haemophilus influenzae, Moraxella catarrhalis, and Neisseria spp. with MIC90s less than or equal to 0.06 μg/mL[2]. Cadrofloxacin against members of the family Enterobacteriaceae with MIC90s of 0.015 to 16 μg/mL (median MIC90, 0.06 μg/mL)[2].

[In Vivo]

Cadrofloxacin (9 mg/kg; i.g.; once or twice daily for 14 consecutive days) increases the activity of hepatic CYP2E1 in rats[2]. Animal Model: Male Sprague-Dawley rats weighing 180-220 g[2] Dosage: 9 mg/kg Administration: I.g. once or twice daily for 14 consecutive days Result: Enhanced the expression of hepatic CYP2E1 mRNA, inducing a 1.6-fold increase compared with that of control rats. The level of CYP2E1 protein in the hepatic microsomes was significantly higher than control group, 190% of that in control rats.

[References]

[1]. Bryskier A, et al. Fluoroquinolones and tuberculosis. Expert Opin Investig Drugs. 2002 Feb;11(2):233-58.

[2]. Biedenbach DJ, et al. Antimicrobial activity of CS-940, a new trifluorinated quinolone. Antimicrob Agents Chemother. 1995 Oct;39(10):2325-30.

[3]. Bryskier A, et al. Fluoroquinolones and tuberculosis. Expert Opin Investig Drugs. 2002 Feb;11(2):233-58.

Chemical & Physical Properties

[ Density]:
1.458g/cm3

[ Boiling Point ]:
602.4ºC at 760mmHg

[ Molecular Formula ]:
C₁₉H₂₀F₃N₃O₄

[ Molecular Weight ]:
411.37500

[ Flash Point ]:
318.1ºC

[ Exact Mass ]:
411.14100

[ PSA ]:
83.80000

[ LogP ]:
2.96700

[ Vapour Pressure ]:
2.33E-15mmHg at 25°C

[ Index of Refraction ]:
1.588