DBCO-PEG4-C2-acid

Names

[ Name ]:
DBCO-PEG4-C2-acid

[Synonym ]:
4,7,10,13-Tetraoxa-16-azaeicosan-1-oic acid, 20-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-17,20-dioxo-
ADIBO-PEG4-acid
MFCD22380749
20-(11,12-Didehydrodibenzo[b,f]azocin-5(6H)-yl)-17,20-dioxo-4,7,10,13-tetraoxa-16-azaicosan-1-oic acid

Biological Activity

[Description]:

DBCO-PEG4-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
839.7±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₀H₃₆N₂O₈

[ Molecular Weight ]:
552.615

[ Flash Point ]:
461.7±34.3 °C

[ Exact Mass ]:
552.247192

[ LogP ]:
2.08

[ Appearance of Characters ]:
Solid or Viscous Liquid

[ Vapour Pressure ]:
0.0±3.3 mmHg at 25°C

[ Index of Refraction ]:
1.597

[ Storage condition ]:
-20°C

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Related Compounds

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