(Rac)-Plevitrexed

Names

[ Name ]:
(Rac)-Plevitrexed

Biological Activity

[Description]:

(Rac)-Plevitrexed ((Rac)-ZD 9331; (Rac)-BGC9331) is a racemate of Plevitrexed. Plevitrexed is an orally active and potent thymidylate synthase (TS) inhibitor.

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Thymidylate Synthase

Research Areas >> Others

[References]

[1]. Tochowicz A, et al. Development and binding mode assessment of N-[4-[2-propyn-1-yl[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-3H-cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-l-γ-glutamyl-D-glutamic acid (BGC 945), a novel thymidylate synthase inhibitor that targets tumor cells. J Med Chem. 2013 Jul 11;56(13):5446-55.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₆H₂₅FN₈O₄

[ Molecular Weight ]:
532.53

Related Compounds

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