(R)-Plevitrexed

Names

[ Name ]:
(R)-Plevitrexed

[Synonym ]:
(2r)-2-[(2-fluoro-4-{[(4-hydroxy-2,7-dimethylquinazolin-6-yl)methyl](prop-2-yn-1-yl)amino}benzoyl)amino]-4-(2h-tetrazol-5-yl)butanoic acid
UNII-7PC8918P3Q

Biological Activity

[Description]:

(R)-Plevitrexed ((R)-ZD 9331; (R)-BGC9331) is a less active enantiomer of Plevitrexed[1]. Plevitrexed is an orally active and potent thymidylate synthase (TS) inhibitor[2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Marsham PR, et al. Design and synthesis of potent non-polyglutamatable quinazoline antifolatethymidylate synthase inhibitors. J Med Chem. 1999 Sep 23;42(19):3809-20.

[2]. Tochowicz A, et al. Development and binding mode assessment of N-[4-[2-propyn-1-yl[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-3H-cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-l-γ-glutamyl-D-glutamic acid (BGC 945), a novel thymidylate synthase inhibitor that targets tumor cells. J Med Chem. 2013 Jul 11;56(13):5446-55.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₆H₂₅FN₈O₄

[ Molecular Weight ]:
532.52600

[ Exact Mass ]:
532.19800

[ PSA ]:
173.60000

[ LogP ]:
2.63480

Related Compounds

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