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Ginkgolide K

Names

[ CAS No. ]:
153355-70-5

[ Name ]:
Ginkgolide K

[Synonym ]:
(1S,3R,6R,7R,8S,10R,11R,12R,13R)-6,12-Dihydroxy-16-methyl-8-(2-methyl-2-propanyl)-2,4,14,19-tetraoxahexacyclo[8.7.2.01,11.03,7.07,11.013,17]nonadec-16-ene-5,15,18-trione
MFCD28124368
6H-9,4a-(Epoxymethano)-3aH,9H-cyclopenta[c]furo[2,3-b]furo[3',2':3,4]cyclopenta[1,2-d]furan-2,6,13(1H)-trione, 11-(1,1-dimethylethyl)-7a,8,10,11-tetrahydro-1,8-dihydroxy-5-methyl-, (1R,3aR,4aS,7aR,8R,8aR,9R,11S,11aR)-

Biological Activity

[Description]:

Ginkgolide K, isolated from Ginkgo biloba, induces protective autophagy through the AMPK/mTOR/ULK1 signaling pathway. Ginkgolide K possesses neuroprotective activity[1].

[Related Catalog]:

Signaling Pathways >> Autophagy >> Autophagy
Research Areas >> Neurological Disease

[References]

[1]. Zhang Y, et al. Ginkgolide K promotes astrocyte proliferation and migration after oxygen-glucose deprivation via inducing protective autophagy through the AMPK/mTOR/ULK1 signaling pathway. Eur J Pharmacol. 2018 Aug 5;832:96-103.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
743.5±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C20H22O9

[ Molecular Weight ]:
406.383

[ Flash Point ]:
269.8±26.4 °C

[ Exact Mass ]:
406.126373

[ LogP ]:
0.48

[ Vapour Pressure ]:
0.0±5.6 mmHg at 25°C

[ Index of Refraction ]:
1.649

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds