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Tos-PEG6-CH2-Boc

Names

[ CAS No. ]:
1530777-90-2

[ Name ]:
Tos-PEG6-CH2-Boc

[Synonym ]:
2-Methyl-2-propanyl 20-{[(4-methylphenyl)sulfonyl]oxy}-3,6,9,12,15,18-hexaoxaicosan-1-oate
3,6,9,12,15,18-Hexaoxaeicosan-1-oic acid, 20-[[(4-methylphenyl)sulfonyl]oxy]-, 1,1-dimethylethyl ester

Biological Activity

[Description]:

Tos-PEG6-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Snaebjornsson MT, et al. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways. Exp Mol Med. 2018 Apr 16;50(4):34.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
611.2±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C25H42O11S

[ Molecular Weight ]:
550.659

[ Flash Point ]:
323.5±31.5 °C

[ Exact Mass ]:
550.244812

[ LogP ]:
1.14

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.490

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds