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Tos-PEG1-CH2-Boc

Names

[ CAS No. ]:
1643957-24-7

[ Name ]:
Tos-PEG1-CH2-Boc

[Synonym ]:
Acetic acid, 2-[2-[[(4-methylphenyl)sulfonyl]oxy]ethoxy]-, 1,1-dimethylethyl ester
2-Methyl-2-propanyl (2-{[(4-methylphenyl)sulfonyl]oxy}ethoxy)acetate
MFCD28122953

Biological Activity

[Description]:

Tos-PEG1-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Snaebjornsson MT, et al. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways. Exp Mol Med. 2018 Apr 16;50(4):34.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
449.0±30.0 °C at 760 mmHg

[ Molecular Formula ]:
C15H22O6S

[ Molecular Weight ]:
330.397

[ Flash Point ]:
225.4±24.6 °C

[ Exact Mass ]:
330.113708

[ LogP ]:
2.93

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.503

Related Compounds