Cyclo(-Gly-His)

Names

[ Name ]:
Cyclo(-Gly-His)

[Synonym ]:
(S)-3-(1H-Imidazol-4-ylmethyl)-2,5-piperazinedione
CYCLO(GLY-L-HIS)
cyclo-Gly-His
cyclo-(glycyl-L-histidyl)

Biological Activity

[Description]:

Cyclo(Gly-His) is a liposome-encapsulated cyclic dipeptide with antimicrobial and anticancer activity. Cyclo(Gly-His) has cytotoxicity for HeLa and MCF-7 cell with IC50 values of 1.699 mM and 0.358 mM, respectively. Cyclo(Gly-His) can be used for the research of drug delivery systems[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[Target]

IC50: 1.699 mM (HeLa cell) and 0.358 mM (MCF-7 cell)[1].

[In Vitro]

Cyclo(Gly-His) 对 HeLa 和 MCF-7 细胞具有细胞毒性，IC50 值分别为 1.699 mM 和 0.358 mM[1]。

[References]

[1]. Kilian G, et al. Anticancer activity of the liposome-encapsulated cyclic dipeptides, cyclo(His-Gly) and cyclo(His-Ala). Pharmazie. 2013;68(3):207-211.

Chemical & Physical Properties

[ Molecular Formula ]:
C₈H₁₀N₄O₂

[ Molecular Weight ]:
194.19

[ Exact Mass ]:
194.08000

[ PSA ]:
86.88000

Safety Information

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

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