BMY 45778

Names

[ Name ]:
BMY 45778

[Synonym ]:
Tocris-1442
2-[3-[4-(4,5-diphenyl-1,3-oxazol-2-yl)-1,3-oxazol-5-yl]phenoxy]acetic acid

Biological Activity

[Description]:

BMY 45778 is a non-prostanoid prostacyclin mimetic. BMY 45778 inhibits human (IC50 = 35 nM), rabbit (IC50: 136 nM) and rat (IC50 : 1.3 μM) platelet aggregation. BMY 45778 also activates adenylyl cyclase. BMY 45778 is a partial agonist at the prostacyclin receptor[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> GPCR/G Protein >> Adenylate Cyclase

Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor

[References]

[1]. Seiler SM, et al. [3-[4-(4,5-Diphenyl-2-oxazolyl)-5-oxazolyl]phenoxy]acetic acid (BMY 45778) is a potent non-prostanoid prostacyclin partial agonist: effects on platelet aggregation, adenylyl cyclase, cAMP levels, protein kinase, and iloprost binding. Prostaglandins. 1997 Jan;53(1):21-35.

Chemical & Physical Properties

[ Density]:
1.298g/cm3

[ Boiling Point ]:
659.9ºC at 760 mmHg

[ Molecular Formula ]:
C₂₆H₁₈N₂O₅

[ Molecular Weight ]:
438.43

[ Flash Point ]:
352.9ºC

[ Exact Mass ]:
438.12200

[ PSA ]:
98.59000

[ LogP ]:
5.79400

[ Vapour Pressure ]:
2.59E-18mmHg at 25°C

[ Index of Refraction ]:
1.617

Related Compounds

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