BTG 1640

Names

[ CAS No. ]:
152538-59-5

[ Name ]:
BTG 1640

Biological Activity

[Description]:

BTG 1640 (ABIO-08/01) is a potent anxiolytic isoxazoline. BTG 1640 is a selective inhibitor of GABA- and glutamate-gated chloride channels[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Chloride Channel
Research Areas >> Neurological Disease

[Target]

GABA- and glutamate-gated chloride channels[1]


[In Vivo]

BTG 1640 (ABIO-08/01) 在小鼠和大鼠焦虑模型中单次腹腔注射和单次口服给药（灌胃）后，以极低剂量显示活性。长期给药既没有导致耐受性的发展，也没有在突然停止治疗后出现戒断症状[2]。

[References]

[1]. Correll CU, et al. The future of psychopharmacology: a critical appraisal of ongoing phase 2/3 trials, and of some current trends aiming to de-risk trial programmes of novel agents. World Psychiatry. 2023 Feb;22(1):48-74.  

[2]. Saletu-Zyhlarz GM, et al. Double-blind, placebo-controlled, multiple-ascending-dose study on the pharmacodynamics of ABIO-08/01, a new CNS drug with potential anxiolytic activity. 1. EEG mapping, psychometric and tolerability findings. Neuropsychobiology. 2009;59(2):100-9.  

Chemical & Physical Properties

[ Molecular Formula ]:
C15H19NO2

[ Molecular Weight ]:
245.32

Related Compounds

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