N-{4-[(4-Chloro-1-piperidinyl)sulfonyl]phenyl}-5-nitro-2-furamide

Names

[ Name ]:
N-{4-[(4-Chloro-1-piperidinyl)sulfonyl]phenyl}-5-nitro-2-furamide

[Synonym ]:
N-{4-[(4-Chloro-1-piperidinyl)sulfonyl]phenyl}-5-nitro-2-furamide
2-Furancarboxamide, N-[4-[(4-chloro-1-piperidinyl)sulfonyl]phenyl]-5-nitro-

Biological Activity

[Description]:

ML291 is a UPR (unfolded protein response)-inducing sulfonamidebenzamide. ML291 overwhelms the adaptive capacity of the UPR and induces apoptosis in a variety of solid cancer models. ML291 can activate the PERK/eIF2a/CHOP (apoptotic) arm of the UPR and reduce leukemic cell burden[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Eukaryotic Initiation Factor (eIF)

Signaling Pathways >> Cell Cycle/DNA Damage >> PERK

[References]

[1]. Danielle Garshott, et al. The Novel Sulfonamidebenzamide ML291 Activates Apoptotic UPR Signaling in Pediatric Leukemia. Blood. 2016,128(22):3523.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Molecular Formula ]:
C₁₆H₁₆ClN₃O₆S

[ Molecular Weight ]:
413.83

[ Exact Mass ]:
413.044830

[ LogP ]:
2.78

[ Index of Refraction ]:
1.652

Safety Information

[ RIDADR ]:
NONH for all modes of transport