GT 2016

Names

[ Name ]:
GT 2016

[Synonym ]:
Grifolic acid

Biological Activity

[Description]:

GT-2016 is a potent, selective, and brain penetrant histamine H3 receptor antagonist with a Ki of 43.8 nM. GT-2016 displays selectivity against H1 and H2 receptors, and has non-active against histamine methyltransferase[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> Histamine Receptor

[Target]

H3 Receptor:43.8 nM (Ki)

[References]

[1]. C E Tedford, et al. Pharmacological characterization of GT-2016, a non-thiourea-containing histamine H3 receptor antagonist: in vitro and in vivo studies. J Pharmacol Exp Ther. 1995 Nov;275(2):598-604.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₃₁N₃O

[ Molecular Weight ]:
317.46900

[ Exact Mass ]:
317.24700

[ PSA ]:
48.99000

[ LogP ]:
4.19430

Related Compounds

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