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Aphadilactone C

Names

[ CAS No. ]:
1522004-70-1

[ Name ]:
Aphadilactone C

[Synonym ]:
(4S,7S)-4-(5,5-Dimethyl-4-oxo-4,5-dihydro-2-furanyl)-2,2-dimethyl-4,7-bis{(4E)-4-methyl-5-[(2S)-4-methyl-6-oxo-3,6-dihydro-2H-pyran-2-yl]-4-penten-1-yl}-4,5,6,7-tetrahydro-1-benzofuran-3(2H)-one
3(2H)-Benzofuranone, 4-(4,5-dihydro-5,5-dimethyl-4-oxo-2-furanyl)-4,7-bis[(4E)-5-[(2S)-3,6-dihydro-4-methyl-6-oxo-2H-pyran-2-yl]-4-methyl-4-penten-1-yl]-4,5,6,7-tetrahydro-2,2-dimethyl-, (4S,7S)-

Biological Activity

[Description]:

Aphadilactone C is a potent and selective DGAT-1 inhibitor with an IC50 of 0.46 μM. Aphadilactone C shows significant antimalarial activities with an IC50 value of 170 nM[1].

[Related Catalog]:

Research Areas >> Infection

[References]

[1]. Jia Liu, et al. Aphadilactones A-D, four diterpenoid dimers with DGAT inhibitory and antimalarial activities from a Meliaceae plant. J Org Chem. 2014 Jan 17;79(2):599-607.  

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
815.4±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C40H52O8

[ Molecular Weight ]:
660.84

[ Flash Point ]:
328.5±34.3 °C

[ Exact Mass ]:
660.366211

[ PSA ]:
105.20000

[ LogP ]:
6.61

[ Vapour Pressure ]:
0.0±2.9 mmHg at 25°C

[ Index of Refraction ]:
1.566

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds