Estetrol

Names

[ Name ]:
Estetrol

[Synonym ]:
ESTETROL
15|A-Hydroxyestriol

Biological Activity

[Description]:

Estetrol, a natural estrogen synthesized exclusively during pregnancy by the human fetal liver, is a selective nuclear estrogen receptor modulator. Estetrol exerts estrogenic actions on the endometrium or the central nervous system but presents antagonistic effects on the breast[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Estrogen Receptor/ERR

Research Areas >> Cardiovascular Disease

[Target]

Estrogen receptor[1]

[References]

[1]. Valéra MC, et al. Effect of estetrol, a selective nuclear estrogen receptor modulator, in mouse models of arterial and venous thrombosis. Mol Cell Endocrinol. 2018 Dec 5;477:132-139.

[2]. Montt-Guevara MM, et al. Estetrol Modulates Endothelial Nitric Oxide Synthesis in Human Endothelial Cells. Front Endocrinol (Lausanne). 2015 Jul 22;6:111.

Chemical & Physical Properties

[ Density]:
1.343 g/cm3

[ Boiling Point ]:
491.9ºC at 760 mmHg

[ Molecular Formula ]:
C₁₈H₂₄O₄

[ Molecular Weight ]:
304.38100

[ Flash Point ]:
231.7ºC

[ Exact Mass ]:
304.16700

[ PSA ]:
80.92000

[ LogP ]:
1.55080

[ Index of Refraction ]:
1.65

[ Storage condition ]:
-20°C

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Estetrol: a unique steroid in human pregnancy.

J. Steroid Biochem. Mol. Biol. 110(1-2) , 138-43, (2008)

Estetrol (E(4)) is an estrogenic steroid molecule synthesized exclusively by the fetal liver during human pregnancy and reaching the maternal circulation through the placenta. Its function is presentl...

Related Compounds

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