3-(2-Hydroxy-4,6-dimethoxyphenyl)-1-(4-hydroxyphenyl)-1-propanone

Names

[ Name ]:
3-(2-Hydroxy-4,6-dimethoxyphenyl)-1-(4-hydroxyphenyl)-1-propanone

[Synonym ]:
1-Propanone, 3-(2-hydroxy-4,6-dimethoxyphenyl)-1-(4-hydroxyphenyl)-
3-(2-Hydroxy-4,6-dimethoxyphenyl)-1-(4-hydroxyphenyl)-1-propanone

Biological Activity

[Description]:

4',2-Dihydroxy-4,6-dimethoxydihydrochalcone, an estrogen agonist, shows binding affinity for bovine uterine estrogen receptor with an IC5050 of 15 μM[1].

[Related Catalog]:

Signaling Pathways >> Others >> Estrogen Receptor/ERR

Research Areas >> Endocrinology

[Target]

Estrogen receptor

[In Vitro]

4',2-Dihydroxy-4,6-dimethoxydihydrochalcone stimulates the MCF-7 cell proliferation in a concentration dependent manner between 10 nM and 10 μM[1].

[References]

[1]. K Ichikawa, et al. Retrodihydrochalcones and homoisoflavones isolated from Thai medicinal plant Dracaena loureiri and their estrogen agonist activity. Planta Med. 1997 Dec;63(6):540-3.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
532.7±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₇H₁₈O₅

[ Molecular Weight ]:
302.322

[ Flash Point ]:
196.7±23.6 °C

[ Exact Mass ]:
302.115417

[ LogP ]:
2.80

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.594

Related Compounds

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