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4'-Hydroxy-2,4-dimethoxychalcone

Names

[ CAS No. ]:
151135-64-7

[ Name ]:
4'-Hydroxy-2,4-dimethoxychalcone

[Synonym ]:
2-Propen-1-one, 3-(2,4-dimethoxyphenyl)-1-(4-hydroxyphenyl)-, (2E)-
(2E)-3-(2,4-dimethoxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one
(2E)-3-(2,4-Dimethoxyphenyl)-1-(4-hydroxyphenyl)-2-propen-1-one

Biological Activity

[Description]:

4'-Hydroxy-2,4-dimethoxychalcone is a natural chalcone derivatives in the red herbal resin of Dracaena cochinchinensis. 4'-Hydroxy-2,4-dimethoxychalcone displays a wide range of biological activities including antimalarial, antiprotozoal, antibacterial, antifungal activity[1][2].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Fungal
Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

4'-Hydroxy-2,4-dimethoxychalcone (compound 2) is against P. falciparum D6 (IC50=4.2 μM) and W2 (IC50=4.8 μM)[1].

[In Vivo]

4'-Hydroxy-2,4-dimethoxychalcone (compound 2; oral; 160 mg/kg) has a T1/2 of 1.94 hours, a Cmax of 158 ng/mL and an AUC of 384 ng•h/mL in four- to five-week-old ICR mice[1].

[References]

[1]. Clare E Gutteridge, et al. In vitro biotransformation, in vivo efficacy and pharmacokinetics of antimalarial chalcones. Pharmacology. 2011;87(1-2):96-104.

[2]. Qing-An Zheng, et al. Flavonoids from the Resin of Dracaena cochinchinensis. Helvetica Chimica Acta, 87(5), 1167–1171.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
500.1±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C17H16O4

[ Molecular Weight ]:
284.306

[ Flash Point ]:
185.8±23.6 °C

[ Exact Mass ]:
284.104858

[ LogP ]:
3.48

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.614

[ Storage condition ]:
2-8℃

Related Compounds