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Trigothysoid N

Names

[ CAS No. ]:
1501943-08-3

[ Name ]:
Trigothysoid N

[Synonym ]:
(1R,2S,3S,5R,6S,7S,8R,10S,11S,14Z,16Z,18S,19S,22R,24R,25S,26S,28S,30S,31S,33S)-6,7,24,25-Tetrahydroxy-5-(hydroxymethyl)-10,24,31,33-tetramethyl-13-oxo-28-phenyl-4,12,27,29,32-pentaoxaoctacyclo[26.3.1. ;119,22.01,8.02,26.03,5.07,11.025,30]tritriaconta-14,16-dien-18-yl 3-methylbutanoate

Biological Activity

[Description]:

Trigothysoid N is a daphnane diterpenoid with anticancer activity. Trigothysoid N inhibits tumor proliferation and migration by targeting mitochondria, regulating the STAT3/FAK signal pathway, and suppressing angiogenesis. Trigothysoid N also induce apoptosis, can be used for research of non-small cell lung cancer (NSCLC)[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Signaling Pathways >> Stem Cell/Wnt >> STAT
Research Areas >> Cancer
Signaling Pathways >> JAK/STAT Signaling >> STAT
Signaling Pathways >> Metabolic Enzyme/Protease >> MMP

[In Vitro]

Trigothysoid N (5、15 和 45 μM；48 小时) 以剂量依赖性方式抑制肿瘤细胞生长[1]。 Trigothysoid N (5、10 和 20 μM；48 小时) 诱导细胞凋亡并使细胞周期停滞在 G0/G1 期[1]。 Trigothysoid N (5、10 和 20 μM；48 小时) 诱导 MMP 去极化，并增加细胞 ROS 的产生，从而刺激 A549 细胞凋亡[1]。 Trigothysoid N 通过线粒体依赖性信号通路诱导细胞凋亡，并通过调节 FAK 信号通路抑制 A549 细胞转移[1]。 Apoptosis Analysis[1] Cell Line: A549 cells Concentration: 5, 10, and 20 μM Incubation Time: 48 h Result: Resulted the apoptotic cell percentages increased from 9.9% (control) to 12.6% (5.0 μM), 15.4% (10.0 μM), and 59.0% (20.0 μM).

[In Vivo]

Trigothysoid N (0.025、0.05 和 0.1 μM; 4 h) 在转基因斑马鱼模型中显示出抗血管生成活性和抗 A549 肿瘤活性[1]。 Animal Model: Transgenic zebrafish model transplanted with CM-DiI-stained A549 cells[1] Dosage: 0.025, 0.05, and 0.1 μM Administration: Result: Inhibited angiogenesis. Disrupted intersegmental blood vessels (ISVs) and dorsal longitudinal anastomotic vessels (DLAVs) in zebrafish. Inhibited tumor cell proliferation with inhibitory rates of 5.7% (0.025 μM), 14.8% (0.05 μM) and 56.9% (0.1 μM), respectively.

[References]

[1]. Li Y, et al. Trigothysoid N inhibits tumor proliferation and migration by targeting mitochondria and the STAT3/FAK pathway[J]. Arabian Journal of Chemistry, 2023, 16(8): 104930.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C44H58O13

[ Molecular Weight ]:
794.92

[ Exact Mass ]:
794.387756

[ LogP ]:
9.13

[ Index of Refraction ]:
1.639

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds