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GNE-3511

Names

[ CAS No. ]:
1496581-76-0

[ Name ]:
GNE-3511

[Synonym ]:
4-Pyridinecarbonitrile, 2-[[6-(3,3-difluoro-1-pyrrolidinyl)-4-[1-(3-oxetanyl)-4-piperidinyl]-2-pyridinyl]amino]-
2-({6-(3,3-Difluoro-1-pyrrolidinyl)-4-[1-(3-oxetanyl)-4-piperidinyl]-2-pyridinyl}amino)isonicotinonitrile
GNE-3511

Biological Activity

[Description]:

GNE-3511 is a dual leucine zipper kinase (DLK) inhibitor with a Ki of 0.5 nM.

[Related Catalog]:

Signaling Pathways >> MAPK/ERK Pathway >> MAP3K
Research Areas >> Cancer

[References]

[1]. Patel S et al. Discovery of dual leucine zipper kinase (DLK, MAP3K12) inhibitors with activity in neurodegeneration models. J Med Chem. 2015 Jan 8;58(1):401-18.


[Related Small Molecules]

Takinib | Selonsertib(GS-4997) | NG25 | 5Z-7-Oxozeaenol | NQDI 1 | GS-444217 | B-Raf inhibitor

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
579.0±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C23H26F2N6O

[ Molecular Weight ]:
440.489

[ Flash Point ]:
304.0±30.1 °C

[ Exact Mass ]:
440.213623

[ LogP ]:
2.01

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.630

[ Storage condition ]:
2-8℃

Related Compounds