Sardomozide

Names

[ Name ]:
Sardomozide

[Synonym ]:
2-(4-aminoiminomethyl)-2,3-dihydro-1H-inden-1-ylidene dihydrochloride
(E)-2-(4-carbaMiMidoyl-2,3-dihydro-1H-inden-1-ylidene)hydrazinec
SardoMozide
4-amidinoindan-1-one 2'-amidinohydrazone
4-amidinoindan-1-ne 2'-amidinohydrazone dihydrochloride

Biological Activity

[Description]:

Sardomozide is an S-adenosylmethionine decarboxylase (SAMDC) inhibitor with an IC50 of 5 nM.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Cancer

[Target]

IC50: 5 nM (SAMDC)[1]

[In Vitro]

Sardomozide is a S-adenosylmethionine decarboxylase (SAMDC) inhibitor with an IC50 of 5 nM in cell assay. Following treatment for 48 h with 3 μM Sardomozide, intracellular SAMDC activity is reduced to 10% of control[1]. When the CHO/664 cells are grown in the presence of Sardomozide and during treatment with DENSPM, vacuole formation is not observed, and these cells are growth-inhibited and contain levels of DENSPM similar to the parental CHO cells[2].

[Cell Assay]

The parent CHO cell line is chronically exposed to increasing levels of Sardomozide for at least eight passages beginning at 0.1 μM. Cell lines are serially exposed to increasing concentrations until a panel of sublines is obtained resistant to 1 (CHO/1). 3 (CHO/3), 10 (CHO/10), 30 (CHO/30), and 100 (CHO/100) μM Sardomozide for comparative studies[2].

[References]

[1]. Regenass U, et al. CGP 48664, a new S-adenosylmethionine decarboxylase inhibitor with broad spectrum antiproliferative and antitumor activity. Cancer Res. 1994 Jun 15;54(12):3210-7.

[2]. Kramer DL, et al. Lysosomal sequestration of polyamine analogues in Chinese hamster ovary cells resistant to the S-adenosylmethionine decarboxylase inhibitor, CGP-48664. Cancer Res. 1998 Sep 1;58(17):3883-90.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.54g/cm3

[ Boiling Point ]:
490.6ºC at 760mmHg

[ Molecular Formula ]:
C₁₁H₁₄N₆

[ Molecular Weight ]:
230.26900

[ Flash Point ]:
250.5ºC

[ Exact Mass ]:
230.12800

[ PSA ]:
124.13000

[ LogP ]:
2.09500

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.768

[ Storage condition ]:
2-8℃

Safety Information

[ HS Code ]:
2928000090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2928000090

[ Summary ]:
2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%