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149400-88-4 1443105-76-7
138794-73-7

149400-88-4

149400-88-4 structure
149400-88-4 structure
  • Name: Sardomozide
  • Chemical Name: (E)-2-(4-carbamimidoyl-2,3-dihydro-1H-inden-1-ylidene)hydrazinecarboximidamide
  • CAS Number: 149400-88-4
  • Molecular Formula: C11H14N6
  • Molecular Weight: 230.26900
  • Catalog: Research Areas Cancer
  • Create Date: 2018-12-26 12:58:20
  • Modify Date: 2024-01-09 09:14:50
  • Sardomozide is an S-adenosylmethionine decarboxylase (SAMDC) inhibitor with an IC50 of 5 nM.
Name (E)-2-(4-carbamimidoyl-2,3-dihydro-1H-inden-1-ylidene)hydrazinecarboximidamide
Synonyms 2-(4-aminoiminomethyl)-2,3-dihydro-1H-inden-1-ylidene dihydrochloride
(E)-2-(4-carbaMiMidoyl-2,3-dihydro-1H-inden-1-ylidene)hydrazinec
SardoMozide
4-amidinoindan-1-one 2'-amidinohydrazone
4-amidinoindan-1-ne 2'-amidinohydrazone dihydrochloride
Description Sardomozide is an S-adenosylmethionine decarboxylase (SAMDC) inhibitor with an IC50 of 5 nM.
Related Catalog
Target

IC50: 5 nM (SAMDC)[1]
In Vitro Sardomozide is a S-adenosylmethionine decarboxylase (SAMDC) inhibitor with an IC50 of 5 nM in cell assay. Following treatment for 48 h with 3 μM Sardomozide, intracellular SAMDC activity is reduced to 10% of control[1]. When the CHO/664 cells are grown in the presence of Sardomozide and during treatment with DENSPM, vacuole formation is not observed, and these cells are growth-inhibited and contain levels of DENSPM similar to the parental CHO cells[2].
Cell Assay The parent CHO cell line is chronically exposed to increasing levels of Sardomozide for at least eight passages beginning at 0.1 μM. Cell lines are serially exposed to increasing concentrations until a panel of sublines is obtained resistant to 1 (CHO/1). 3 (CHO/3), 10 (CHO/10), 30 (CHO/30), and 100 (CHO/100) μM Sardomozide for comparative studies[2].
References

[1]. Regenass U, et al. CGP 48664, a new S-adenosylmethionine decarboxylase inhibitor with broad spectrum antiproliferative and antitumor activity. Cancer Res. 1994 Jun 15;54(12):3210-7.

[2]. Kramer DL, et al. Lysosomal sequestration of polyamine analogues in Chinese hamster ovary cells resistant to the S-adenosylmethionine decarboxylase inhibitor, CGP-48664. Cancer Res. 1998 Sep 1;58(17):3883-90.
Density 1.54g/cm3
Boiling Point 490.6ºC at 760mmHg
Molecular Formula C11H14N6
Molecular Weight 230.26900
Flash Point 250.5ºC
Exact Mass 230.12800
PSA 124.13000
LogP 2.09500
Vapour Pressure 0mmHg at 25°C
Index of Refraction 1.768
Storage condition 2-8℃
HS Code 2928000090
Precursor  1

DownStream  0

HS Code 2928000090
Summary 2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

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title: CAS No. 149400-88-4 | Chemsrc address: https://www.chemsrc.com/en/baike/899858.html

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