S-15176 difumarate salt

[ Molecular Formula ]:
C₃₉H₅₆N₂O₁₂S

[ Molecular Weight ]:
776.93300

[ Exact Mass ]:
776.35500

[ PSA ]:
228.90000

[ LogP ]:
5.61240

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ RIDADR ]:
NONH for all modes of transport

S-15176 inhibits mitochondrial permeability transition via a mechanism independent of its antioxidant properties.

Eur. J. Pharmacol. 468 , 93-101, (2003)

Mitochondrial Ca(2+) accumulation can induce a sudden increase in the permeability of the inner membrane. This phenomenon is due to the generation of a large nonselective ion channel, termed the perme...

Inhibition of mitochondrial carnitine palmitoyltransferase-1 by a trimetazidine derivative, S-15176.

Pharmaceut. Res. 44 , 99-104, (2001)

The purpose of this study was to investigate the possible effect of the trimetazidine derivative S-15176 on carnitine palmitoyltransferase1 (CPT-1) activity in rat heart and liver mitochondria. S-1517...

S-15176 reduces the hepatic injury in rats subjected to experimental ischemia and reperfusion.

Eur. J. Pharmacol. 406 , 281-292, (2000)

The protective effect of N-[(3, 5-di-tertiobutyl-4-hydroxy-1-thiophenyl)]-3-propyl-N'-(2,3, 4-trimethoxybenzyl)piperazine (S-15176) on liver injury induced by warm ischemia-reperfusion was investigate...

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