LY300503

Names

[ CAS No. ]:
148905-79-7

[ Name ]:
LY300503

Biological Activity

[Description]:

LY300503 is an enantiomer of LY191704. LY191704 is a human type I 5α-reductase inhibitor[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vivo]

LY300503 (30-300 mg/kg; p.o. for 14 d) exhibits the mean dose-normalized AUC value of 56% after the first dose and 38% after the last dose in rats[2].

[References]

[1]. Farid NA, et, al. High-performance liquid chromatographic determination of the enantiomers of the benzoquinolinone LY191704, a human type 1 5 alpha-reductase inhibitor, in plasma. J Chromatogr B Biomed Sci Appl.

[2]. Farid NA, et, al. Stereoselective disposition of the enantiomers of the benzoquinolinone LY191704, a human type I 5 alpha-reductase inhibitor. Differences between rats and dogs. Drug Metab Dispos. 1996 Oct;24(10):1162-5.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄H₁₆ClNO

[ Molecular Weight ]:
249.74

Related Compounds

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