GDP-α-D-mannose disodium

Names

[ Name ]:
GDP-α-D-mannose disodium

[Synonym ]:
GDP-D-mannose disodium salt
Guanosine 5 inverted exclamation marka-diphospho-|A-D-mannose disodium salt

Biological Activity

[Description]:

GDP-α-D-mannose disodium is the donor substrate for mannosyltransferases and the precursor of GDP-β-L-fucose. GDP-α-D-mannose disodium gives a competitive inhibition with respect to GTP (Ki 14.7 μM) and an uncompetitive inhibition with respect to mannose-1-P (Ki 115 μM)[1].

[Related Catalog]:

Research Areas >> Metabolic Disease

[In Vitro]

GDP-α-D-mannose is the alpha-anomer of GDP-D-mannose.

[References]

[1]. Elling L, et al. Expression, purification and characterization of recombinant phosphomannomutase and GDP-alpha-D-mannose pyrophosphorylase from Salmonella enterica, group B, for the synthesis of GDP-alpha-D-mannose from D-mannose. Glycobiology. 1996 Sep;6(6):591-7.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₂₃N₅Na₂O₁₆P₂

[ Molecular Weight ]:
649.30500

[ Exact Mass ]:
649.04100

[ PSA ]:
357.99000

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Related Compounds

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GDP-​α-D-​mannose disodium