GDP-ALPHA-D-MANNOSE, DISODIUM SALT

Names

[ Name ]:
GDP-ALPHA-D-MANNOSE, DISODIUM SALT

[Synonym ]:
GDP-α-D-MANNOSE, DISODIUM SALT

Biological Activity

[Description]:

GDP-α-D-mannose disodium is the donor substrate for mannosyltransferases and the precursor of GDP-β-L-fucose. GDP-α-D-mannose disodium gives a competitive inhibition with respect to GTP (Ki 14.7 μM) and an uncompetitive inhibition with respect to mannose-1-P (Ki 115 μM)[1].

[Related Catalog]:

Research Areas >> Metabolic Disease

[Target]

Human Endogenous Metabolite

[References]

[1]. Elling L, et al. Expression, purification and characterization of recombinant phosphomannomutase and GDP-alpha-D-mannose pyrophosphorylase from Salmonella enterica, group B, for the synthesis of GDP-alpha-D-mannose from D-mannose. Glycobiology. 1996 Sep;6(6):591-7.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₂₃N₅Na₂O₁₆P₂

[ Molecular Weight ]:
649.30

[ Exact Mass ]:
649.04100

[ PSA ]:
357.00000

[ Storage condition ]:
-20°C

Safety Information

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
S26

[ RIDADR ]:
NONH for all modes of transport

Articles

Low glucose depletes glycan precursors, reduces site occupancy and galactosylation of a monoclonal antibody in CHO cell culture.

Biotechnol. J. 10 , 1051-66, (2015)

Controlled feeding of glucose has been employed previously to enhance the productivity of recombinant glycoproteins but there is a concern that low concentrations of glucose could limit the synthesis ...

Structural and Enzymatic Characterization of a Nucleoside Diphosphate Sugar Hydrolase from Bdellovibrio bacteriovorus.

PLoS ONE 10 , e0141716, (2015)

Given the broad range of substrates hydrolyzed by Nudix (nucleoside diphosphate linked to X) enzymes, identification of sequence and structural elements that correctly predict a Nudix substrate or cha...

Aging without Apolipoprotein D: Molecular and cellular modifications in the hippocampus and cortex.

Exp. Gerontol. 67 , 19-47, (2015)

A detailed knowledge of the mechanisms underlying brain aging is fundamental to understand its functional decline and the baseline upon which brain pathologies superimpose. Endogenous protective mecha...

Related Compounds

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