LY210073

Names

[ CAS No. ]:
148291-65-0

[ Name ]:
LY210073

[Synonym ]:
LY210073

Biological Activity

[Description]:

LY210073 is a Leukotriene B4 (LTB4) receptor antagonist with an IC50 of 6.2 nM.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Leukotriene Receptor

Research Areas >> Inflammation/Immunology

[Target]

LTB4:6.2 nM (IC50)

[In Vitro]

LY210073 is a Leukotriene B4 (LTB4) receptor antagonist with an IC50 of 6.2±0.1 nM. LY2100731 (Compound 32) appears to be one of the strongest inhibitors of LTB4 receptor binding reported so far[1].

[References]

[1]. Jackson WT, et al. Design, synthesis, and pharmacological evaluation of potent xanthone dicarboxylic acid leukotriene B4 receptor antagonists. J Med Chem. 1993 Jun 11;36(12):1726-34.

[Related Small Molecules]

MK-571 | Zafirlukast | Pranlukast | Nedocromil | AS-35 | LY223982 | Darbufelone mesilate | LM-1484 | Quinotolast sodium | RG-12525 | RS-601 | Tipelukast | CI-949 | CP 105696 | CP-96486

Chemical & Physical Properties

[ Density]:
1.314g/cm3

[ Boiling Point ]:
775.7ºC at 760mmHg

[ Molecular Formula ]:
C₃₀H₂₈O₈

[ Molecular Weight ]:
516.53900

[ Flash Point ]:
257.2ºC

[ Exact Mass ]:
516.17800

[ PSA ]:
123.27000

[ LogP ]:
5.93270

[ Vapour Pressure ]:
2.52E-25mmHg at 25°C

[ Index of Refraction ]:
1.636

[ Storage condition ]:
2-8℃