RIPK1-IN-4

Names

[ CAS No. ]:
1481641-08-0

[ Name ]:
RIPK1-IN-4

Biological Activity

[Description]:

RIPK1-IN-4 (compound 8) is a potent and selective type II kinase inhibitor of receptor interacting protein 1 (RIP1) kinase and binds to a DLG-out inactive form of RIP1 with an IC50s of 16 nM and 10 nM for RIP1 and ADP-Glo kinase[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> RIP kinase
Research Areas >> Inflammation/Immunology

[Target]

IC50: 16 nM (RIP1) and 10 nM (ADP-Glo)[1]


[References]

[1]. Harris PA, et al. Discovery of Small Molecule RIP1 Kinase Inhibitors for the Treatment of Pathologies Associated with Necroptosis. ACS Med Chem Lett. 2013 Nov 4;4(12):1238-43.

Chemical & Physical Properties

[ Molecular Formula ]:
C23H23N5O2

[ Molecular Weight ]:
401.46

Related Compounds