Cefcapene pivoxil hydrochloride hydrate

Names

[ Name ]:
Cefcapene pivoxil hydrochloride hydrate

[Synonym ]:
CEFCAPENE PIVOXIL HYDROCHLORIDE HYDRATE
[(2,2-Dimethylpropanoyl)oxy]methyl (6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-pentenoyl]amino}-3-[(carbamoyloxy)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride hydrate
Flomox
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[[(aminocarbonyl)oxy]methyl]-7-[[(2Z)-2-(2-amino-4-thiazolyl)-1-oxo-2-penten-1-yl]amino]-8-oxo-, (2,2-dimethyl-1-oxopropoxy)methyl ester, (6R,7R)-, hydrochloride, hydrate (1:1:1)
Cefcapene pivoxil hydrochloride
Cefcapene pivoxil hydrochloride monohydrate

Biological Activity

[Description]:

Cefcapene pivoxil hydrochloride hydrate is a prodrug and an orally active 3rd-generation cephalosporin with broad-spectrum of anti-bacterial activity[1]. Cefcapene pivoxil hydrochloride hydrate is used for the study of palmoplantar pustulosis (PPP) and other infectious diseases[2].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[Target]

IC50: bacterial[1]

[In Vivo]

Cefcapene pivoxil hydrochloride hydrate (oral administration; 100mg/kg; 4 days) is effective against invasive BLNAR strains in mice lung, it stimates peak antibiotic concentrations of 1 to 2 μg/ml in the blood of mice from 30 to 120 min after intragastric administration[3]. Animal Model: Four-week-old female C57BL/6J mice with bacterial suspension in BSG (1×109 CFU)[3] Dosage: 100 mg/kg Administration: Oral administration; 100mg/kg; 4 days Result: Was against H. influenzae colonization in mouse lung.

[References]

[1]. Murakami M, et al. Cefcapene Pivoxil Hydrochloride Is a Potentially New Treatment for Palmoplantar Pustulosis with Pustulotic Arthro-Osteitis.Dermatology. 2015;231(4):304-11.

[2]. Kawada A, et al. Drug eruption induced by cefcapene pivoxil hydrochloride.Contact Dermatitis. 2001 Mar;44(3):197.

[3]. Sekiya Y, et al. Comparative efficacies of different antibiotic treatments to eradicate nontypeable Haemophilus influenzae infection.BMC Infect Dis. 2008 Feb 7;8:15.

[4]. Sekiya Y, et al. Comparative efficacies of different antibiotic treatments to eradicate nontypeable Haemophilus influenzae infection.BMC Infect Dis. 2008 Feb 7;8:15.

Chemical & Physical Properties

[ Density]:
1.47 g/cm3

[ Boiling Point ]:
888.4ºC at 760 mmHg

[ Melting Point ]:
158-164ºC

[ Molecular Formula ]:
C₂₃H₃₂ClN₅O₉S₂

[ Molecular Weight ]:
622.111

[ Flash Point ]:
491.1ºC

[ Exact Mass ]:
621.132996

[ PSA ]:
256.01000

[ LogP ]:
3.70600

[ Vapour Pressure ]:
3.51E-32mmHg at 25°C

[ Storage condition ]:
0-10°C

Safety Information

[ RTECS ]:
XI0325000

[ HS Code ]:
2941905990

Customs

[ HS Code ]: 2941905990