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ω-Conotoxin MVIIC

Names

[ CAS No. ]:
147794-23-8

[ Name ]:
ω-Conotoxin MVIIC

[Synonym ]:
CTX MVIIC
conotoxin MVIIC
omega-Conotoxin M VIIC
{(1R,4S,7S,10S,13S,16S,19S,22R,27R,30S,36S,39S,45R,48S,54S,57R,62R,65S,71S,77S,83S)-62-Amino-7,30,65,71-tetrakis(4-aminobutyl)-4,36,39-tris(3-carbamimidamidopropyl)-27-carbamoyl-16-(4-hydroxybenzyl)-10-(1-hydroxyethyl)-48,54-bis(hydroxymethyl)-77-methyl-13-[2-(methylsulfanyl)ethyl]-2,5,8,11,14,17,20,29,32,35,38,41,44,47,50,53,56,63,66,69,72,75,78,84,91-pentacosaoxo-24,25,59,60,87,88-hexathia-3,6,9,12,15,18,21,28,31,34,37,40,43,46,49,52,55,6
Snx 230
conotoxin MVIIC_smartox
{(1R,4S,7S,13S,16S,19S,22R,27R,30S,36S,39S,45R,48S,54S,57R,62R,65S,71S,77S,83S)-62-Amino-7,30,65,71-tetrakis(4-aminobutyl)-4,36,39-tris(3-carbamimidamidopropyl)-27-carbamoyl-16-(4-hydroxybenzyl)-10-[(1R)-1-hydroxyethyl]-48,54-bis(hydroxymethyl)-77-methyl-13-[2-(methylsulfanyl)ethyl]-2,5,8,11,14,17,20,29,32,35,38,41,44,47,50,53,56,63,66,69,72,75,78,84,91-pentacosaoxo-24,25,59,60,87,88-hexathia-3,6,9,12,15,18,21,28,31,34,37,40,43,46,49,52,55,

Biological Activity

[Description]:

ω-Conotoxin MVIIC is a N- and P/Q-type Ca2+ channel blocker, significantly suppresses the 11-keto-βboswellic acid-mediated inhibition of glutamate release[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel
Research Areas >> Neurological Disease

[References]

[1]. Cheng Wei Lu, et al. 11-Keto-β-Boswellic Acid Attenuates Glutamate Release and Kainic Acid-Induced Excitotoxicity in the Rat Hippocampus. Planta Med. 2020 Apr;86(6):434-441.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Molecular Formula ]:
C106H178N40O32S7

[ Molecular Weight ]:
2749.251

[ Exact Mass ]:
2747.157471

[ PSA ]:
1372.92000

[ LogP ]:
-20.33

[ Index of Refraction ]:
1.723

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
UN 3172

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

Articles

Mechanisms underlying mechanosensitivity of mesenteric afferent fibers to vascular flow.

Am. J. Physiol. Gastrointest. Liver Physiol. 293(2) , G422-8, (2007)

Spinal afferent neurons, with endings in the intestinal mesenteries, have been shown to respond to changes in vascular perfusion rates. The mechanisms underlying this sensitivity were investigated in ...

Glutamate regulates neurite outgrowth of cultured descending brain neurons from larval lamprey.

Dev. Neurobiol. 67(2) , 173-88, (2007)

In larval lamprey, descending brain neurons, which regenerate their axons following spinal cord injury, were isolated and examined in cell culture to identify some of the factors that regulate neurite...

Effects of Ca2+ channel antagonists on acetylcholine and catecholamine releases in the in vivo rat adrenal medulla.

Am. J. Physiol. Regul. Integr. Comp. Physiol. 287(1) , R161-6, (2004)

To elucidate the types of voltage-dependent Ca(2+) channels controlling ACh and catecholamine releases in the in vivo adrenal medulla, we implanted microdialysis probes in the left adrenal medulla of ...


More Articles


Related Compounds

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