ZM 226600

Names

[ Name ]:
ZM 226600

Biological Activity

[Description]:

ZM226600 is an ATP-sensitive potassium channel opener (EC50: 500 nM). ZM226600 inhibits bladder spontaneous activity[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[In Vitro]

ZM226600 (1 μM, 30 min) 抑制膀胱自发活动[1].

[In Vivo]

ZM226600 (10-1000 nmol/kg，静脉注射) 不会显着改变麻醉大鼠的心跳率[1]。

[References]

[1]. Pinna C,et al. Effect of the ATP-sensitive potassium channel opener ZM226600 on cystometric parameters in rats with ligature-intact, partial urethral obstruction. Eur J Pharmacol. 2005 May 23;516(1):71-7.

[2]. Grant TL, et al. Anilide tertiary carbinols: a novel series of K+ channel openers. Trends Pharmacol Sci. 1994 Nov;15(11):402-4.

Chemical & Physical Properties

[ Density]:
1.448g/cm3

[ Boiling Point ]:
574.8ºC at 760 mmHg

[ Molecular Formula ]:
C₁₆H₁₄F₃NO₄S

[ Molecular Weight ]:
373.35

[ Flash Point ]:
301.4ºC

[ Exact Mass ]:
373.06000

[ PSA ]:
91.85000

[ LogP ]:
3.92500

[ Vapour Pressure ]:
4.72E-14mmHg at 25°C

[ Index of Refraction ]:
1.569

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.