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ZM 226600

Names

[ CAS No. ]:
147695-92-9

[ Name ]:
ZM 226600

Biological Activity

[Description]:

ZM226600 is an ATP-sensitive potassium channel opener (EC50: 500 nM). ZM226600 inhibits bladder spontaneous activity[1][2].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[In Vitro]

ZM226600 (1 μM, 30 min) 抑制膀胱自发活动[1].

[In Vivo]

ZM226600 (10-1000 nmol/kg,静脉注射) 不会显着改变麻醉大鼠的心跳率[1]。

[References]

[1]. Pinna C,et al. Effect of the ATP-sensitive potassium channel opener ZM226600 on cystometric parameters in rats with ligature-intact, partial urethral obstruction. Eur J Pharmacol. 2005 May 23;516(1):71-7.  

[2]. Grant TL, et al. Anilide tertiary carbinols: a novel series of K+ channel openers. Trends Pharmacol Sci. 1994 Nov;15(11):402-4.  

Chemical & Physical Properties

[ Density]:
1.448g/cm3

[ Boiling Point ]:
574.8ºC at 760 mmHg

[ Molecular Formula ]:
C16H14F3NO4S

[ Molecular Weight ]:
373.35

[ Flash Point ]:
301.4ºC

[ Exact Mass ]:
373.06000

[ PSA ]:
91.85000

[ LogP ]:
3.92500

[ Vapour Pressure ]:
4.72E-14mmHg at 25°C

[ Index of Refraction ]:
1.569


Related Compounds