Loviride

Names

[ Name ]:
Loviride

[Synonym ]:
Loveride
Loviride (USAN/INN)
loviride

Biological Activity

[Description]:

Loviride (R 89439) is a non-nucleoside reverse transcriptase inhibitor (NNRTI), with IC50s of 0.3 µM for reverse transcriptase from HIV-1. Loviride (R 89439) inhibits HIV-1, HIV-2 and SIV replication in MT-4 cells[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HIV

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Reverse Transcriptase

[Target]

IC50: 0.3 µM (Reverse transcriptase)[1]

[In Vitro]

Loviride (0.01 µM) inhibits HIV-1(IIIB) replication in MT-4 cells, also inhibits HIV-2 and SIV, with EC50s of 85.5, 7.4 µM for HIV-2 (ROD), HIV-2 (EHO), and 11.4, 28.5, 57.0 µM for SIV (mac251), SIV (agm3), SIV (mndGB1), respectively[1].

[References]

[1]. Witvrouw M, et al. Activity of non-nucleoside reverse transcriptase inhibitors against HIV-2 and SIV. AIDS. 1999 Aug 20;13(12):1477-83.

Chemical & Physical Properties

[ Density]:
1.354g/cm3

[ Boiling Point ]:
550.3ºC at 760mmHg

[ Melting Point ]:
226.3 °C

[ Molecular Formula ]:
C₁₇H₁₆Cl₂N₂O₂

[ Molecular Weight ]:
351.22700

[ Flash Point ]:
286.6ºC

[ Exact Mass ]:
350.05900

[ PSA ]:
73.18000

[ LogP ]:
5.36560

[ Vapour Pressure ]:
3.69E-12mmHg at 25°C

[ Index of Refraction ]:
1.637

Related Compounds

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