147362-57-0

147362-57-0 structure

Name: Loviride
Chemical Name: 2-(2-acetyl-5-methylanilino)-2-(2,6-dichlorophenyl)acetamide
CAS Number: 147362-57-0
Molecular Formula: C₁₇H₁₆Cl₂N₂O₂
Molecular Weight: 351.22700
Catalog: Signaling Pathways Anti-infection HIV
Create Date: 2018-08-02 08:56:57
Modify Date: 2025-08-25 12:42:13
Loviride (R 89439) is a non-nucleoside reverse transcriptase inhibitor (NNRTI), with IC50s of 0.3 µM for reverse transcriptase from HIV-1. Loviride (R 89439) inhibits HIV-1, HIV-2 and SIV replication in MT-4 cells[1].

Name	2-(2-acetyl-5-methylanilino)-2-(2,6-dichlorophenyl)acetamide
Synonyms	Loveride Loviride (USAN/INN) loviride

Description	Loviride (R 89439) is a non-nucleoside reverse transcriptase inhibitor (NNRTI), with IC50s of 0.3 µM for reverse transcriptase from HIV-1. Loviride (R 89439) inhibits HIV-1, HIV-2 and SIV replication in MT-4 cells[1].
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection Signaling Pathways >> Anti-infection >> Reverse Transcriptase
Target	IC50: 0.3 µM (Reverse transcriptase)[1]
In Vitro	Loviride (0.01 µM) inhibits HIV-1(IIIB) replication in MT-4 cells, also inhibits HIV-2 and SIV, with EC50s of 85.5, 7.4 µM for HIV-2 (ROD), HIV-2 (EHO), and 11.4, 28.5, 57.0 µM for SIV (mac251), SIV (agm3), SIV (mndGB1), respectively[1].
References	[1]. Witvrouw M, et al. Activity of non-nucleoside reverse transcriptase inhibitors against HIV-2 and SIV. AIDS. 1999 Aug 20;13(12):1477-83.