roridin a
Names
[ CAS No. ]:
14729-29-4
[ Name ]:
roridin a
[Synonym ]:
roridin A from myrothecium sp cryst
roridana
Roridin A,Roridin C
roridinea
Einecs 238-783-8
roridin a from myrothecium sp.
MFCD00055569
7'-Deoxo-7'-[(1R)-1-Hydroxyethyl]-(7'R)-Verrucarin A
Biological Activity
[Description]:
[Related Catalog]:
[References]
Chemical & Physical Properties
[ Density]:
1.29g/cm3
[ Boiling Point ]:
752.4ºC at 760 mmHg
[ Molecular Formula ]:
C29H40O9
[ Molecular Weight ]:
532.62200
[ Flash Point ]:
246ºC
[ Exact Mass ]:
532.26700
[ PSA ]:
124.05000
[ LogP ]:
2.39340
[ Vapour Pressure ]:
3.92E-26mmHg at 25°C
[ Index of Refraction ]:
1.58
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- VL0355000
- CHEMICAL NAME :
- Roridin A
- CAS REGISTRY NUMBER :
- 14729-29-4
- LAST UPDATED :
- 198708
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C29-H40-O9
- MOLECULAR WEIGHT :
- 532.69
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - guinea pig
- REFERENCE :
- FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 4,S124,1984 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 9 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - muscle contraction or spasticity
- REFERENCE :
- TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 23,731,1985
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 500 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DFSCDX Developments in Food Science. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1978- Volume(issue)/page/year: 4,135,1983
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- BIBIAU Biotechnology and Bioengineering. (John Wiley & Sons, Inc., 605 Third Ave., New York, NY 10158) V.4- 1962- Volume(issue)/page/year: 10,445,1968
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 2300 ug/kg
- TOXIC EFFECTS :
- Gastrointestinal - ulceration or bleeding from large intestine Gastrointestinal - hypermotility, diarrhea
- REFERENCE :
- TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 23,731,1985
Safety Information
[ Hazard Codes ]:
T+: Very toxic;
[ Risk Phrases ]:
R28
[ Safety Phrases ]:
28-36/37-45
[ RIDADR ]:
UN 3462 6.1/PG 1
[ Hazard Class ]:
6.1(a)