Durlobactam sodium salt

Names

[ Name ]:
Durlobactam sodium salt

Biological Activity

[Description]:

Durlobactam sodium salt (ETX2514) is a broad-spectrum β-lactamase inhibitor with IC50s of 4, 14 and 190 nM for Class A KPC-2, Class C AmpC and Class D OXA-24, respectively. For the treatment of drug-resistant Gram-negative bacteria including Acinetobacter baumannii[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[Target]

IC50: 4 nM (Class A KPC-2), 14 nM (Class C AmpC), 190 nM (Class D OXA-24)[1].

[References]

[1]. Durand-Réville TF, et al. ETX2514 is a broad-spectrum β-lactamase inhibitor for the treatment of drug-resistant Gram-negative bacteria including Acinetobacter baumannii. Nat Microbiol. 2017 Jun 30;2:17104.

Chemical & Physical Properties

[ Molecular Formula ]:
C₈H₁₀N₃NaO₆S

[ Molecular Weight ]:
299.24

Related Compounds

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