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(4-Oxo-4H-quinazolin-3-yl)-acetic acid

Names

[ CAS No. ]:
14663-53-7

[ Name ]:
(4-Oxo-4H-quinazolin-3-yl)-acetic acid

[Synonym ]:
4-Oxo-3,4-dihydro-chinazolyl-3-essigsaeure
2-(4-oxo-3-hydroquinazolin-3-yl)acetic acid
(4-Oxo-4H-quinazolin-3-yl)-acetic acid
(4-oxo-3,4-dihydroquinazolin-3-yl)acetic acid
(4-Oxo-4H-chinazolin-3-yl)-essigsaeure
3-carboxymethyl-3,4-dihydro-4(1H)-quinazolinone
(4-oxoquinazolin-3(4H)-yl)acetic acid
N-carboxymethyl-4(3H)-quinazolinone
2-(4-oxo-3,4-dihydroquinazolin-3-yl)acetic acid
2-(4-Oxoquinazolin-3(4H)-yl)acetic acid
3(4h)-quinazolineacetic acid,4-oxo
(4-oxo-3,4-dihydroquinazolin-3-yl)acetate

Biological Activity

[Description]:

(4-Oxo-4H-quinazolin-3-yl)-acetic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl-Chain


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Boiling Point ]:
444.6ºC at 760mmHg

[ Molecular Formula ]:
C10H8N2O3

[ Molecular Weight ]:
204.18200

[ Exact Mass ]:
204.05300

[ PSA ]:
72.19000

[ LogP ]:
0.48110

[ Vapour Pressure ]:
1.1E-08mmHg at 25°C

[ Index of Refraction ]:
1.659

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

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