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JG26

Names

[ CAS No. ]:
1464910-32-4

[ Name ]:
JG26

Biological Activity

[Description]:

JG26 is an ADAM17 inhibitor, with IC50 values of 12 nM, 1.9 nM, 150 nM and 9.4 nM for ADAM8, ADAM17, ADAM10 and MMP-12, respectively[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> MMP

[Target]

ADAM17:1.9 nM (IC50)

ADAM8:12 nM (IC50)

ADAM10:150 nM (IC50)

MMP-9:>500000 nM (IC50)

MMP-8:240 nM (IC50)

MMP-9:1630 nM (IC50)

MMP-12:9.4 nM (IC50)

MMP14:19500 nM (IC50)


[References]

[1]. Doretta Cuffaro, et al. Discovery of Dimeric Arylsulfonamides as Potent ADAM8 Inhibitors. ACS Med Chem Lett. 2021 Oct 8;12(11):1787-1793.

Chemical & Physical Properties

[ Molecular Formula ]:
C19H22Br2N4O6S

[ Molecular Weight ]:
594.27

Related Compounds