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Zaragozic acid B

Names

[ CAS No. ]:
146389-61-9

[ Name ]:
Zaragozic acid B

[Synonym ]:
Zaragozic acid B

Biological Activity

[Description]:

Zaragozic acid B, a fungal metabolite, is a potent inhibitor of both farnesyl-protein transferase (FPTase) and squalene synthases. Zaragozic acid B is a potential anticancer drug[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> Farnesyl Transferase

[In Vitro]

Zaragozic acid B is a very potent inhibitor of squalene synthases from all three sources (RSS: rat liver microsome; YSS: Candida albicans; HSS: Hep G2 cells) with the IC50 values range from 0.22 to 0.67 nM[1]. Zaragozic acid B inhibits bovine FPTase (IC50=100 nM), human FPTase (IC50=185 nM)[1].

[References]

[1]. Leeyuan Huang, et al. New fungal metabolites as potential antihypercholesterolemics and anticancer agents. Canadian Journal of Botany • December 1995.

Chemical & Physical Properties

[ Density]:
1.3g/cm3

[ Boiling Point ]:
871.6ºC at 760mmHg

[ Molecular Formula ]:
C39H54O13

[ Molecular Weight ]:
730.83800

[ Flash Point ]:
260.4ºC

[ Exact Mass ]:
730.35600

[ PSA ]:
217.35000

[ LogP ]:
4.87800

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.593

Related Compounds