BI-2081

Names

[ CAS No. ]:
1458656-71-7

[ Name ]:
BI-2081

Biological Activity

[Description]:

BI-2081 is a GPR40 (FFAR1) partial agonist (EC50: 4 nM). BI-2081 induces glucose depending insulin secretion and reduces the plasma glucose concentration. BI-2081 can be used in the research of metabolic diseases, in particular diabetes type 2[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> GPR40
Research Areas >> Metabolic Disease

[Target]

GPR40 (FFAR1)[1]


[References]

[1]. Governa P, et al. FFAR1/GPR40: One target, different binding sites, many agonists, no drugs, but a continuous and unprofitable tug-of-war between ligand lipophilicity, activity, and toxicity. Bioorg Med Chem Lett. 2021 Jun 1;41:127969.

Chemical & Physical Properties

[ Molecular Formula ]:
C32H35FO6

[ Molecular Weight ]:
534.62

Related Compounds