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Lilotomab

Names

[ CAS No. ]:
1453362-55-4

[ Name ]:
Lilotomab

Biological Activity

[Description]:

Lilotomab (HH1) is a murine anti-CD37 monoclonal antibody. Lilotomab reduces clonogenic survival. Lilotomab shows anti-tumor activity[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[Target]

CD37[1]


[In Vitro]

Lilotomab (0-40 µg/mL; 12 days) 降低 DOHH2 和 Ramos 细胞的克隆形成存活率[1]。 Lilotomab (40 µg/mL; 18 h) 诱导 DOHH2 细胞轻微凋亡[1]。 Apoptosis Analysis[1] Cell Line: Ramos, DOHH2, Rec-1 cells Concentration: 40 µg/mL Incubation Time: 18 h Result: Induced apoptosis in DOHH2 cells.

[In Vivo]

Lilotomab (0.5 mg/kg；i.v.；一次) 抑制小鼠肿瘤生长[1]。 Animal Model: SCID mice (DOHH2 cell xenografts)[1] Dosage: 0.5 mg/kg Administration: I.v.; once Result: Inhibited tumor growth and increased mouse survival.

[References]

[1]. Malenge MM, et al. 177Lu-Lilotomab Satetraxetan Has the Potential to Counteract Resistance to Rituximab in Non-Hodgkin Lymphoma. J Nucl Med. 2020 Oct;61(10):1468-1475.  

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds

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