1453362-55-4

1453362-55-4 structure

1453362-55-4 structure

Name: Lilotomab
Chemical Name: Lilotomab
CAS Number: 1453362-55-4
Molecular Formula:
Molecular Weight:
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2023-05-08 10:19:31
Modify Date: 2024-04-09 09:17:36
Lilotomab (HH1) is a murine anti-CD37 monoclonal antibody. Lilotomab reduces clonogenic survival. Lilotomab shows anti-tumor activity[1].

Name	Lilotomab

Description	Lilotomab (HH1) is a murine anti-CD37 monoclonal antibody. Lilotomab reduces clonogenic survival. Lilotomab shows anti-tumor activity[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Others >> Others
Target	CD37[1]
In Vitro	Lilotomab (0-40 µg/mL; 12 days) 降低 DOHH2 和 Ramos 细胞的克隆形成存活率[1]。 Lilotomab (40 µg/mL; 18 h) 诱导 DOHH2 细胞轻微凋亡[1]。 Apoptosis Analysis[1] Cell Line: Ramos, DOHH2, Rec-1 cells Concentration: 40 µg/mL Incubation Time: 18 h Result: Induced apoptosis in DOHH2 cells.
In Vivo	Lilotomab (0.5 mg/kg；i.v.；一次) 抑制小鼠肿瘤生长[1]。 Animal Model: SCID mice (DOHH2 cell xenografts)[1] Dosage: 0.5 mg/kg Administration: I.v.; once Result: Inhibited tumor growth and increased mouse survival.
References	[1]. Malenge MM, et al. 177Lu-Lilotomab Satetraxetan Has the Potential to Counteract Resistance to Rituximab in Non-Hodgkin Lymphoma. J Nucl Med. 2020 Oct;61(10):1468-1475.

No Any Chemical & Physical Properties