5-benzyloxygramine

Names

[ Name ]:
5-benzyloxygramine

[Synonym ]:
5-benzyloxy-N,N-dimethylamino-3-methylindole
EINECS 215-927-8
5-Benzyloxy-gramin
5-Benzyloxygramine
MFCD00005631

Biological Activity

[Description]:

5-Benzyloxygramine is a N protein PPI orthosteric stabilizer that exhibits both antiviral and N-NTD protein-stabilizing activities[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

5-benzyloxygramine stabilizes the N-NTD dimers through simultaneous hydrophobic interactions with both partners, resulting in abnormal N protein oligomerization that was further confirmed in the cell[1].

[References]

[1]. Shan-Meng Lin, et al. Structure-Based Stabilization of Non-native Protein-Protein Interactions of Coronavirus Nucleocapsid Proteins in Antiviral Drug Design. J Med Chem. 2020 Mar 26;63(6):3131-3141.

Chemical & Physical Properties

[ Density]:
1.153g/cm3

[ Boiling Point ]:
442.3ºC at 760mmHg

[ Melting Point ]:
137-139 °C(lit.)

[ Molecular Formula ]:
C₁₈H₂₀N₂O

[ Molecular Weight ]:
280.36400

[ Flash Point ]:
221.3ºC

[ Exact Mass ]:
280.15800

[ PSA ]:
28.26000

[ LogP ]:
3.80850

[ Vapour Pressure ]:
5.06E-08mmHg at 25°C

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
C: Corrosive;Xi: Irritant;

[ Risk Phrases ]:
R34

[ Safety Phrases ]:
S45-S36/37/39-S26

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%