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SBI-425

Names

[ CAS No. ]:
1451272-71-1

[ Name ]:
SBI-425

[Synonym ]:
MFCD31652984

Biological Activity

[Description]:

SBI-425 is a potent, selective and oral bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor[1]. Long-term administration of SBI-425 effectively reaches and inhibits TNAP in the vasculature, improving cardiovascular parameters and survival at a dose that does not cause a detectable change in bone[2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase

[References]

[1]. Pinkerton AB, et al. Discovery of 5-((5-chloro-2-methoxyphenyl)sulfonamido)nicotinamide (SBI-425), a potent and orally bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor. Bioorg Med Chem Lett. 2018 Jan 1;28(1):31-34.

[2]. Sheen CR, et al. Pathophysiological role of vascular smooth muscle alkaline phosphatase in medial artery calcification. J Bone Miner Res. 2015 May;30(5):824-36.

Chemical & Physical Properties

[ Molecular Formula ]:
C13H12ClN3O4S

[ Molecular Weight ]:
341.77

[ Storage condition ]:
-20°C

Related Compounds