sodium dehydrocholate

Names

[ CAS No. ]:
145-41-5

[ Name ]:
sodium dehydrocholate

[Synonym ]:
Dycholium
Dehydrocholic acid sodium salt
3,7,12-Trioxo-5b-cholan-24-oic Acid Monosodium Salt
Biliton
Biliron
3,7,12-Trioxo-5b-cholan-24-oic Acid Sodium Salt
Natriumdehydrocholat
Decholin sodium salt
sodium dehydrocholate
(5b)-3,7,12-Trioxocholan-24-oic Acid Sodium Salt
SodiuMDehydrocholic
Sodium (5β)-3,7,12-trioxocholan-24-oate
Carachol
dilabilsodium
decholinsodium
MFCD00150750
Sodium 3,7,12-Trioxo-5b-cholan-24-oate
Cholan-24-oic acid, 3,7,12-trioxo-, sodium salt, (5β)-
Sodium 3,7,12-triketocholanate
Dehydrocholate sodium
Sodium 3,7,12-Trioxo-5b-cholanate
dehydrocholic acid monosodium salt
Cholan-24-oic acid, 3,7,12-trioxo-, sodium salt, (5β)- (1:1)
Dilabil sodium
Sodium 3,7,12-trioxo-5β-cholan-24-oate
Decholin sodium
EINECS 205-652-1
decholinsodiumsalt
BILITON SODIUM SALT
Suprachol
Dehydrocholate (sodium)

Biological Activity

[Description]:

Dehydrocholic sodium is a hydrocholeretic, increasing bile output to clear increased bile acid load.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Others

[Related Small Molecules]

Chemical & Physical Properties

[ Boiling Point ]:
581.5ºC at 760mmHg

[ Melting Point ]:
>300°C

[ Molecular Formula ]:
C₂₄H₃₃NaO₅

[ Molecular Weight ]:
424.506

[ Flash Point ]:
319.5ºC

[ Exact Mass ]:
424.222565

[ PSA ]:
91.34000

[ LogP ]:
2.73860

[ Index of Refraction ]:
27 ° (C=5, H2O)

[ Water Solubility ]:
H2O: 0.1 M at 20 °C, clear, colorless

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FZ2500000

CHEMICAL NAME :: 5-beta-Cholan-24-oic acid, 3,7,12-trioxo-, sodium salt

CAS REGISTRY NUMBER :: 145-41-5

LAST UPDATED :: 199701

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C24-H33-O5.Na

MOLECULAR WEIGHT :: 424.56

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3755 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GWXXBX German Offenlegungsschrift Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2630169

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CHTPBA Chimica Therapeutica. (Paris, France) V.1-8, 1965-73. For publisher information, see EJMCA5. Volume(issue)/page/year: 5,188,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2300 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: YOIZA3 Yonago Igaku Zasshi. Journal of the Yonago Medical Association. (c/o Tottori Daigaku Igakabu, 86 Nishi-machi, Yonago, Japan) V.1- 1948- Volume(issue)/page/year: 25,70,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 887 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New York, NY) V.1-3, 1964-72. Discontinued. Volume(issue)/page/year: 2,280,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2150 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: YOIZA3 Yonago Igaku Zasshi. Journal of the Yonago Medical Association. (c/o Tottori Daigaku Igakabu, 86 Nishi-machi, Yonago, Japan) V.1- 1948- Volume(issue)/page/year: 25,70,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1480 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New York, NY) V.1-3, 1964-72. Discontinued. Volume(issue)/page/year: 2,280,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1350 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: YOIZA3 Yonago Igaku Zasshi. Journal of the Yonago Medical Association. (c/o Tottori Daigaku Igakabu, 86 Nishi-machi, Yonago, Japan) V.1- 1948- Volume(issue)/page/year: 25,70,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1100 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: YOIZA3 Yonago Igaku Zasshi. Journal of the Yonago Medical Association. (c/o Tottori Daigaku Igakabu, 86 Nishi-machi, Yonago, Japan) V.1- 1948- Volume(issue)/page/year: 25,70,1974

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Cardiac - other changes Gastrointestinal - other changes Blood - other changes

REFERENCE :: ZGEMAZ Zeitschrift fuer die Gesamte Experimentelle Medizin. (Berlin, Fed. Rep. Ger.) V.1-139, 1913-65. For publisher information, see REXMAS. Volume(issue)/page/year: 52,779,1926

Safety Information

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
S22-S36

[ WGK Germany ]:
3

[ RTECS ]:
FZ2500000